Daniel L. Kiss, Ph.D. (Principal Investigator)

OrcidLinkedin@Kiss_RNA_Lab

Daniel L. Kiss, Ph.D. is an Assistant Professor in the Department of Cardiovascular Sciences and a member of the Cardiovascular Regeneration and RNA Therapeutics Programs at the Houston Methodist Research Institute (HMRI) in Houston, Texas.  Dr. Kiss is also an Associate Research Member of the Houston Methodist Cancer Center and holds an appointment as an Assistant Professor of Molecular Biology in Medicine at Weill Cornell Medical College.

Dr. Kiss grew up in a West-side suburb of Cleveland, Ohio.  As the son of two immigrants from Hungary, he’s both a #FirstGen American and college graduate.  He earned both his B.S. and M.S. in Biology from Cleveland State University in Cleveland, Ohio.  He was first introduced to RNA biology when he completed his master’s thesis studying transcriptional regulation in Dr. Tomasz Kordula’s (currently at Virginia Commonwealth University) laboratory.  He then completed his doctoral and postdoctoral training at institutions with large and vibrant RNA biology research communities.

He earned his Ph.D. in Molecular Biology and Microbiology from Case Western Reserve University in 2010, where he was part of the Center for RNA Molecular Biology (now The Center for RNA Science and Therapeutics).  His doctoral work in the lab of Dr. Erik Andrulis focused on how the RNA exosome, the predominant RNA degradation machine for mammalian cells, was regulated and functioned in RNA processing and turnover.

He then moved to The Ohio State University for his postdoctoral research where he was part of The Center for RNA Biology.  Under the supervision of Dr. Daniel Schoenberg, he earned a Pelotonia postdoctoral fellowship to begin his cytoplasmic capping research.  He then secured a second postdoctoral fellowship as Oncology Training Grant (T32) fellow to continue his cytoplasmic capping research.  He also collaborated with other groups at Ohio State, where he was the lead author on three published paper that examine the mechanism by which the FHIT tumor suppressor controls the translation of certain cancer-linked mRNAs. He continues his focus on cytoplasmic capping of RNAs and FHIT-mediated translational regulation at the HMRI.

As an independent principal investigator, Dr. Kiss contributes to the broader scientific community.  He’s served as a peer reviewer for multiple journals, participated in an NIH study Section, is an active member of multiple scientific societies related to his research, and is committed to outreach efforts to raise awareness, interest, and diversity in biomedical research.  His perspective as both a #firstgen American and first generation academic scientist strongly inform his approaches to mentoring, fostering opportunities, and community service.

Outside of the lab, Dan enjoys cycling, traveling, watching sports (baseball, soccer, and college football) and above all, spending time with his wife and his daughter.

Trinh Tat, Ph.D. (Research Associate)

Orcid

Before coming to the United States, Trinh earned both a B.S. in Biotechnology and M.S. in Genetics from the VNUHCM University of Science – Ho Chi Minh City, Vietnam.  Upon completion of her Master’s degree, Trinh was awarded a prestigious Vietnam Education Foundation Fellowship to pursue her Ph.D. in the United States.  In 2009 she joined the lab of Dr. Tim Nilsen at Case Western Reserve University (CWRU) in Cleveland, OH where her research focused on the regulation of mRNA stability by deadenylation elements and miRNAs.  She completed her research and received her Ph.D. degree in Biochemistry in August of 2015.  Immediately after completing her Ph.D. she joined Coller Lab at The Center for RNA Science and Therapeutics, CWRU as postdoctoral researcher.  Her work in the Coller Lab focused on investigating the mechanism of action of drugs for targeting certain CFTR mutations.

In 2016, as a condition of her Vietnam Education Foundation Fellowship she returned to Vietnam to share her training.  During these two years, she gained industry experience as she was appointed as Regulatory and Technical Relations Manager at Procter & Gamble.

Dr. Tat joined the Kiss RNA Lab on December 3, 2018.  Her current research projects include designing, constructing, and experimentally evaluating novel RNA therapeutic candidates.  She is also pursuing bioinformatics training and is being co-mentored by Dr. Kaifu Chen.  She has utilized that informatics training and data mining techniques to predict and evaluate putative cytoplasmic recapping sites in mammalian cells.

Outside the lab, she enjoys traveling and spending time with her family and friends. Experiencing new cultures, enjoying new natural spaces and meeting new people are always on her top to do list during her vacation. She also enjoys doing flower arrangement and interior design whenever she has some time to spare.

Ming Zhang headshot

Min Zhang, Ph.D. (Postdoctoral Fellow)

Orcid

Min earned her B.S. degree in Biological Engineering from the renowned Xiamen University in China. After that, she earned her Ph.D. in Cell Biology from the University of Science and Technology of China, which is a member of the C9 League, China`s equivalent of the Ivy League. Min joined Dr. Tao Zhu`s lab for her Ph.D. research where she was first introduced to cancer biology. Her thesis work was focused on exploring the pivotal roles of a hypoxia-induced secreted protein in hepatocellular carcinoma progression and another secreted factor involved in the transformation of non-malignant human mammary epithelial cells. She completed her research and received her Ph.D. degree in 2016.

She came to United States and began her postdoctoral training at Houston Methodist to study the transcription factors to modulate memory T cell formation. She then transferred to Dr. Kaifu Chen`s lab in Department of Cardiovascular Science. During these two years, she studied the chromatin remodeling factors driving the prostate cancer progression. Min joined the Kiss RNA Lab in October of 2020. Her current research projects include cytoplasmic recapping and developing multiple RNA therapeutic candidates to target glioblastoma multiforme.

Outside the lab, Min enjoys spending time with her husband and daughter. She also enjoys cooking Chinese food, baking, and reading novels.

Rolando Alvarado

Rolando Alvarado (Research Assistant II)

Rolando Alvarado has been a research technician in the Kiss RNA Lab at the Houston Methodist Research Institute for a little over 2 years.

Rolando Alvarado was born in the Rio Grande Valley a few minutes north of the US-Mexico border. Rolando excelled at the South Texas High School for Health Professions in the Rio Grande Valley and was awarded a Terry Foundation scholarship.  As a Terry Foundation scholar, Rolando received an all-expenses paid scholarship to a public university in Texas.  Rolando selected the University of Houston where he completed his Bachelors of Science (graduating with Honors) majoring in Biochemistry, minoring in Chemistry. During his final year, he became interested in research during a nucleic acids course. Upon completion of the course, he volunteered and trained under the mentorship of Dr. Preethi Gunaratne and one of her graduate students.

After graduating, Rolando was hired by the Kiss RNA Lab to work on the cytoplasmic recapping project.  With the mentoring of Dr. Kiss on this project, Rolando has learned dozens of different lab techniques and assays.  His contributions to the lab’s work were recognized as was included as a co-author in the Kiss RNA Lab’s first publication. Rolando is currently contributing both to the lab’s cytoplasmic capping project and has been a key driver of the lab’s SARS-CoV-2 vaccine effort.

Outside of the lab, Rolando enjoys sampling various hobbies like tinkering on vehicles to small home-improvement projects. He enjoys taking on new challenges outside of his scope to gain new practical skills. His pride and joy comes from playing with and training his Doberman pinscher, Hera. He and his wife hope to train her as a licensed service dog to help counter the negative-stigma that often is associated with the breed.

Amelia Khoo headshot

Amelia Khoo (EnMed Student)

Amelia is a 2nd year medical student in EnMed, a dual-degree MD-MEng program at the Texas A&M College of Medicine. She originally hails from Alameda, California. She earned her B.Sc. with Honors in Biomedical Engineering at Brown University in Providence, Rhode Island, where she conducted her honors thesis on vascularization trends in patterned engineered cardiac tissue for regenerative medicine in the lab of Dr. Kareen Coulombe. For her senior capstone project, she helped design a laparoscopic stapler attachment that adapts the tool for individuals of varying hand sizes. She has also partnered with clinicians at UCSF to design and prototype a device for streamlined control of the neurosurgical microscope. Following graduation, Amelia worked as a healthcare consultant at Triage Consulting Group and a volunteer music therapist for hospice patients. As a medical student, Amelia is passionate about reducing the barriers which contribute to healthcare disparities and the ways in which design and technology can be applied to these issues.

Amelia enjoys singing, playing Ultimate Frisbee, calligraphy, and trying out new baking recipes. Despite being new to Texas, she is enjoying all that Houston has to offer, although she is currently welcoming any and all tips for adjusting to the heat!

Blake Melton (Research Technician I)

Blake is currently pursuing his Bachelor of Science degree in Biology with a minor in Psychology at Texas Southern University with aspirations of becoming an Anesthesiologist and obtaining a Ph.D. in Cancer Biology. Blake is actively involved on his campus and holds leadership positions. He is a part of the Student Government Association where he currently serves as Deputy Attorney General, Texas Southern University’s N.A.A.C.P chapter where he serves as the Juvenile Justice Chair, Residential Life and Housing where he is a Resident Assistant, he is a part of the Thomas F. Freeman Honors College at Texas Southern University, and is the Director of Educational Activities for his current chapter the Delta Theta Chapter of Alpha Phi Alpha Fraternity Inc.

In his free time, Blake enjoys reading books, fishing, watching basketball, football, and soccer, exploring new music, serving his community, and watching movies/TV series. However, most of all, he loves obtaining all kinds of knowledge!

Shaun Stevenson (Research Technician I)

Shaun was born and raised in Mansfield, TX where he attended Mansfield High School, graduating with honors. After graduating Shaun received a presidential scholarship-granting him a full scholarship to attend Texas Southern University where he is currently enrolled as a junior. At Texas Southern, Shaun is pursuing his B.S. in biology while being a member of the Thomas F. Freeman Honors College.

Shaun has had a passion for science for as long as he can remember. One of Shaun’s main beliefs is that to effectively practice medicine, you must fully understand the science behind it. After being awarded the opportunity to attend the Annual Medical Education Conference, where he spoke to multiple physicians who were also researchers, he discovered what the field had to offer and acquired an interest in diving further into research. With that in mind, upon graduating from Texas Southern he plans to pursue an MD/PhD with the goal of becoming a physician. Shaun’s future career aspirations include providing healthcare and engagement resources to underprivileged minority communities in the US and around the world.

Outside of the lab, Shaun enjoys cooking, watching sports, and lastly most dear to him, giving back to his community. Shaun is a member of multiple school organizations at Texas Southern University including the Minority Association of Pre-Medical Scholars and the Student Government Association where he serves as the Academic Affairs Senator. Through these organizations, Shaun has had the opportunity to give back to the community by tutoring students at local Houston high schools.

Past members:

Keisha Hardeman, Ph.D.